IMPACT Grand Rounds: Learn As you Go (LAGO) Design
- Roybal Coordinating Center

- 16 minutes ago
- 1 min read
Thursday, February 19, 2026 | 12:00 – 1:00 pm ET

Donna Spiegelman, Sc.D., is the Susan Dwight Bliss Professor of Biostatistics at Yale University’s School of Public Health and Director of Yale’s Center for Methods in Implementation and Prevention Science (CMIPS). She is a former NIH Director’s Pioneer Award recipient (2014–2020), recognized for her work developing innovative methods for implementation and prevention science.
Dr. Spiegelman’s research focuses on the development, adaptation, and dissemination of rigorous methodological approaches to address the unique challenges of implementation research. Her work spans the design of stepped wedge, cluster randomized, and “Learn as You Go” trials; causal inference for non-randomized implementation studies; mediation analysis to elucidate pathways linking implementation strategies, implementation outcomes, and health outcomes; methods for assessing spillover effects within social and organizational networks; and approaches to enhance the external generalizability of implementation studies to support scale-up and scale-out. She leads and supports implementation research aimed at preventing cervical cancer, cardiometabolic disease, and HIV/AIDS across diverse settings in the United States, Nepal, Mexico, South Africa, and Uganda.
About IMPACT Grand Rounds
The IMPACT Collaboratory is hosting webinars on the 3rd Thursday of each month, addressing issues in conducting embedded pragmatic clinical trials on non-pharmacological interventions for people living with dementia and their care partners. The next session will feature Donna Spiegelman, Sc.D.
