IMPACT Collaboratory 2025 Demonstration Projects Grants Program
- Roybal Coordinating Center
- Oct 23
- 1 min read
The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory has launched a Request for Applications for the 2025 Demonstration Projects Grants Program.
The IMPACT Collaboratory will fund up to two Demonstration Projects, each providing up to $800,000 in total direct costs over a 24-month period. The awards will support full-scale, Stage IV effectiveness embedded Pragmatic Clinical Trials (ePCTs) (based on the NIH Stage Model). Projects must evaluate the effectiveness of non-pharmacological interventions embedded within health care systems for people living with dementia (PLWD) and their care partners.
The goal of the Demonstration Project is to generate evidence on effective care delivery practices that can be expanded and implemented in other systems.
For more information, download the full Request for Applications, join the informational webinar on October 30th (see details below), and visit our Demonstration Projects Program webpage. Learn more about our previous Demonstration Project Grant Awardees here.
Awards are for 18 months, up to $300,000 (total direct costs), and are non-renewable. Read the full RFA here.
Important Dates
Informational Webinar
Thursday, October 30, 2025 @ 12:00 PM ET
Provides an overview of the program and addresses applicant questions.
Letters of Intent (LOI) – Required
Due: Thursday, November 13, 2025 @ 11:59 pm ET
Full Proposals (By invitation only)
Applications selected for further consideration will be invited to submit a full proposal. Due: January 15, 2026 @ 11:59pm ET
If you have any questions regarding these funding opportunities, please refer to the Frequently Asked Questions or email IMPACTcollaboratory@hsl.harvard.edu