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The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) is pleased to announce a new request for applications for the 2023 Career Development Award (CDA). These CDAs support the development of MD, PhD, or equivalent researchers who seek careers conducting embedded pragmatic clinical trials (ePCTs) for people living with AD/ADRD and their care partners.


Informational Webinar:

May 30, 2023 @ 2pm ET


Application Period Opens:

May 31, 2023


Proposals Due:

September 15, 2023 @ 5pm ET


This mechanism will fund research projects that are preparatory to conducting a future ePCT such as secondary data analysis, intervention development or the development of pragmatic outcomes. The proposed CDA project cannot include a clinical trial (including pilot trials; see NIH definition of a clinical trial). The IMPACT Collaboratory will fund up to two 1-year CDAs, prioritizing applications that address dementia care for people of all backgrounds and promote health equity. Each award will provide $100,000 annually in direct costs with an indirect cost rate capped at 8%. Awardees are required to devote a minimum of 75% effort toward the goals of the award. Applicants are typically within 7 years of their post-doctoral training program at the time of application. Exceptions will be made in this round of funding for investigators with more than 7 years who can demonstrate evidence of changing their career path to pursue research on ePCTs among PLWD. Such applicants must request prior approval.

A set of frequently asked questions (FAQ) regarding this award is available online at https://impactcollaboratory.org/CDA-grant-faq/. Click here to learn about previous awardees. Email IMPACTcollaboratory@hsl.harvard.edu with questions.







RFA-AG-24-011 - Research Coordinating Center on the Exposome and Alzheimer's Disease (AD) and AD-Related Dementias (ADRD): Elucidating the Role of Social and Behavioral Determinants of Health in AD/ADRD Etiology and Disparities (U24 Clinical Trial Not Allowed)

The NOFO invites applications that propose to establish a national coordinating center that will serve as a centralized hub for accessing, harmonizing, linking, and sharing environmental contextual data and individual exposure data with NIA/NIH-funded projects. The aim of this initiative is to foster collaboration and accelerate life course research on the social, behavioral, psychological, and economic exposures that shape Alzheimer’s disease (AD) and AD-related dementias (ADRD) outcomes and inequities.

Applications to establish the AD/ADRD Exposome Coordinating Center must identify five to seven social, behavioral, psychological, and economic exposome domains relevant to AD/ADRD, and describe activities related to the domains that will achieve the following objectives of this NOFO:

  1. To develop an organizational and governance structure to support the administration, innovation, and dissemination functions of the center.

  2. To propose activities to establish guidance and practices for the use and harmonization of exposure data across NIA-supported infrastructure projects, as well as other longitudinal studies of aging. Additionally, to propose and support activities for the development of innovative and novel exposure measures and data.

  3. To disseminate resources and products developed by the center to the broader AD/ADRD research community to expand the use of social and behavioral data and harmonized measures in a wide range of studies.

For Innovation and Dissemination activities throughout the course of this initiative, applicants must engage with a wide range of NIA-supported AD/ADRD infrastructure projects, such as the centers in the NIA Research Centers Collaborative Network (RCCN), and with other NIA-funded programs and centers.

Applications are due September 27, 2023.

A technical webinar will be held on April 20, 2023 at 2:00 pm Eastern Time. NOT-AG-23-010 - Notice of Pre-Application Webinar for RFA-AG-24-011 - Research Coordinating Center on the Exposome and AD/ADRD: Elucidating the Role of Social and Behavioral Determinants of Health in AD/ADRD Etiology and Disparities (U24 Clinical Trial Not Allowed).







Deadline: January 13, 2023

The Research Centers Collaborative Network (RCCN) goal is to catalyze enduring, collaborative, interdisciplinary research projects across NIA center programs by funding pilot, planning or meeting grants of up to $65,000. Proposals should address topics spanning the missions of multiple NIA Center programs. Relevant topics are exemplified by the themes of RCCN-sponsored workshops. Each project should involve at least two NIA-sponsored research centers. There are two deadlines annually and up to two awards will be granted each cycle.

Additional Details:

The RCCN sponsors a series of workshops addressing specific problems of high salience to multiple NIA Center programs. These workshops feature the sharing of paradigms, conceptual models, and key insights from perspectives of the participating centers programs. Workshops include:

After the workshops, publications are developed summarizing the proceedings and priority areas; past publications are available here. Proposals that address topics that are relevant to the workshops will be considered for this RFA.

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