IMPACT Collaboratory Requests Applications for Real World Data Scholars Program

In collaboration with the NEXT STEPs Network and the Long-Term Care (LTC) Data Cooperative, the National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) is now accepting applications for the 2025 Real World Data Scholars Program.

The 1-year mentored training program is designed to build practical skills and professional networks for postdoctoral fellows, advanced graduate students, and early-career investigators, interested in using real-world data (RWD) to improve care of people living in nursing homes and assisted living communities, including people living with dementia. 

Up to four awards, each providing up to $60,000 will be granted to postdoctoral fellows, graduate students, and early-career investigators to gain mentored training and experience using RWD to improve long-term care.

Scholars will be matched with a program mentor to support their training, project development, and engagement in the program. They will also complete a research project using data from the LTC Data Cooperative to develop or validate measures applicable to clinical trials within nursing homes and assisted living communities. Scholars are expected to independently complete all analytic and scholarly work.

Additionally, scholars will have opportunities to engage in the activities of the IMPACT Collaboratory and NEXT STEPs Network, including Grand Rounds, training opportunities, and annual meetings that foster interdisciplinary exchange, professional development, and methodological advances.

Read the full RFA here

Informational Webinar

An optional informational webinar will be hosted to provide investigators with an overview of application details and an opportunity to ask questions.

December 8, 2025 @ 12:00 PM ET: Register here.

Applications are due January 15, 2026 @ 11:59pm ET

Questions? Please contact, Elaine Bergman, IMPACT Communications Lead

IMPACT Collaboratory 2025 Career Development Award Program

The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) is now accepting applications for the 2025 Career Development Award (CDA) Program. These CDAs support the development of MD, PhD, or equivalent researchers who seek careers conducting embedded pragmatic clinical trials (ePCTs) for people living with AD/ADRD and their care partners.

This mechanism will fund research projects that are preparatory to conducting a future ePCT such as secondary data analysis, intervention development or the development of outcomes to be used in ePCTs. The proposed CDA project cannot include a clinical trial (including pilot trials; see NIH definition of a clinical trial).

The IMPACT Collaboratory will fund up to two awards. Each award will provide $240,000 in total direct costs over two years. Facilities & administrative (indirect) costs may not exceed 8% of total direct costs. Each year, at least $20,000 in direct costs must be allocated for research-related expenses, such as travel, publication costs, analytic, technical or project support, data acquisition, certified translations, or other activities directly related to the goals of the award. Awardees are required to devote a minimum of 50% effort toward the goals of the award.

Read the full RFA here.

Important Dates

Informational Webinar

An optional informational webinar will be hosted to provide investigators with an overview of application details and an opportunity to ask questions.

 December 3, 2025 @ 12:00 PM ET: Register here.

Applications are due January 15, 2026 @ 11:59pm ET

Click here to view full RFA

Questions? Please contact, Elaine Bergman, IMPACT Communications Lead

IMPACT Collaboratory 2025 Demonstration Projects Grants Program

The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory has launched a Request for Applications for the 2025 Demonstration Projects Grants Program.

The IMPACT Collaboratory will fund up to two Demonstration Projects, each providing up to $800,000 in total direct costs over a 24-month period. The awards will support full-scale, Stage IV effectiveness embedded Pragmatic Clinical Trials (ePCTs) (based on the NIH Stage Model). Projects must evaluate the effectiveness of non-pharmacological interventions embedded within health care systems for people living with dementia (PLWD) and their care partners.

The goal of the Demonstration Project is to generate evidence on effective care delivery practices that can be expanded and implemented in other systems.

For more information, download the full Request for Applications, join the informational webinar on October 30th (see details below), and visit our Demonstration Projects Program webpage. Learn more about our previous Demonstration Project Grant Awardees here.

Awards are for 18 months, up to $300,000 (total direct costs), and are non-renewable. Read the full RFA here.

Important Dates

Informational Webinar

Thursday, October 30, 2025 @ 12:00 PM ET

Provides an overview of the program and addresses applicant questions.

Registration is required. 

Letters of Intent (LOI) – Required

Due: Thursday, November 13, 2025 @ 11:59 pm ET

Full Proposals (By invitation only)

Applications selected for further consideration will be invited to submit a full proposal. Due: January 15, 2026 @ 11:59pm ET

If you have any questions regarding these funding opportunities, please refer to the Frequently Asked Questions or email IMPACTcollaboratory@hsl.harvard.edu

Click here to view full RFA