IMPACT Collaboratory 2025 Demonstration Projects Grants Program

The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease (AD) and AD-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory has launched a Request for Applications for the 2025 Demonstration Projects Grants Program.

The IMPACT Collaboratory will fund up to two Demonstration Projects, each providing up to $800,000 in total direct costs over a 24-month period. The awards will support full-scale, Stage IV effectiveness embedded Pragmatic Clinical Trials (ePCTs) (based on the NIH Stage Model). Projects must evaluate the effectiveness of non-pharmacological interventions embedded within health care systems for people living with dementia (PLWD) and their care partners.

The goal of the Demonstration Project is to generate evidence on effective care delivery practices that can be expanded and implemented in other systems.

For more information, download the full Request for Applications, join the informational webinar on October 30th (see details below), and visit our Demonstration Projects Program webpage. Learn more about our previous Demonstration Project Grant Awardees here.

Awards are for 18 months, up to $300,000 (total direct costs), and are non-renewable. Read the full RFA here.

Important Dates

Informational Webinar

Thursday, October 30, 2025 @ 12:00 PM ET

Provides an overview of the program and addresses applicant questions.

Registration is required. 

Letters of Intent (LOI) – Required

Due: Thursday, November 13, 2025 @ 11:59 pm ET

Full Proposals (By invitation only)

Applications selected for further consideration will be invited to submit a full proposal. Due: January 15, 2026 @ 11:59pm ET

If you have any questions regarding these funding opportunities, please refer to the Frequently Asked Questions or email IMPACTcollaboratory@hsl.harvard.edu

Click here to view full RFA

Request for Applications for NIA IMPACT's Pilot Grants Program

The IMPACT Collaboratory is pleased to announce a Request for Applications for the 2025 Pilot Grants Program. The National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) Clinical Trials (IMPACT) Collaboratory (U54AG063546) was established in 2019 to build the nation’s capacity to conduct embedded pragmatic clinical trials (ePCTs) of non-pharmacological interventions within health care systems to improve the care of people living with dementia (PLWD) and their care partners.

The IMPACT Collaboratory will fund up to three awards for pilot pragmatic clinical trials (ePCTs) that that are designed to demonstrate the feasibility and inform the design of a future full-scale ePCT (Stage IV effectiveness based on the NIH Stage Model) to evaluate non-pharmacological interventions embedded in health care system(s) for PLWD and their care partners.

Awards are for 18 months, up to $300,000 (total direct costs), and are non-renewable. Read the full RFA here.

Important Dates

Informational Webinar

An optional informational webinar will be hosted to provide investigators with an overview of application details and an opportunity to ask questions.

Thursday, October 23, 2025, at 1:00pm ET: Register here.

Letters of Intent (LOI) – Required

Interested applicants are required to submit an LOI. LOIs are accepted on a rolling basis through: Thursday, November 6, 2025, at 11:59pm ET

Full Proposals (By invitation only)

Applications selected for further consideration will be invited to submit a full proposal due:

Thursday, February 12, 2026, at 11:59pm ET.

Click here to view full RFA

NIH Common Fund Complement-ARIE Reduction to Practice Prize

The NIH Common Fund has teamed up with NASA’s Tournament Lab to launch the Reduction to Practice Prize, a competition that invites innovative New Approach Methodologies (NAMs) solutions from teams who can successfully demonstrate implementation of integrated human-based solutions in a practical and usable form within a 3-year period.

The goal of this challenge is to accelerate and catalyze near-ready combinatorial NAMs to a practicable form that can be submitted to the Complement-ARIE Validation and Qualification Network (VQN), managed by the Foundation for NIH.

This challenge has three phases:

• Phase 1: Proof of Concept and Feasibility Studies: Phase 1 submissions will include a clear description of intended use for the proposed combinatorial NAM solution.

• Phase 2: Prototype Development and Milestone Achievements: Phase 2 will be milestone-driven. Solvers will demonstrate:

  • Milestone 1: Progress toward meeting the initial performance and testing requirements of the NAMs platform in a specific context-of-use and successful construction and scaling of the NAMs platform according to fit-for-purpose needs.

  • Milestone 2: Progress toward internal validation of the NAMs platform using reference standards/compounds/agents and demonstrated within-laboratory reproducibility of results. 

• Phase 3: Prototype Delivery for Validation and Qualification: Top-scoring submissions will be delivered to the VQN for independent validation and qualification.

The total cash prize purse for this competition is $7,000,000 to be shared among winners.

Submit your ideas by Mar 01, 2026 at 11:59PM ET

Questions?

Reach out to email: gethelp@herox.com 

Click here to learn more