top of page
pexels-jopwell-2422293.jpg

Earlier, more accurate detection and intervention is essential for improving treatment and care options for people living with Alzheimer’s disease or a related dementia, and for supporting care partners. But detecting the early signs of these diseases is challenging.

Scientists continue to seek innovations to improve clinical approaches used in identifying individuals at risk for developing dementia. Current methods have drawbacks such as cost, complexity, and accessibility.


Enter by January 31 to compete for part of the $650K prize

To spark innovation in this critical area, NIA has launched the PREPARE: Pioneering Research for Early Prediction of AD & Related Dementias EUREKA Challenge with a total combined prize purse of $650,000.

The multiyear challenge spans three phases:

  • Phase I: Participants will focus on finding, curating, or contributing data to open datasets representative of diverse populations that can be used for early prediction of Alzheimer’s and related dementias. Examples of data sources include NIH-supported research studies, electronic health records, and Centers for Medicare & Medicaid Services claims. All challenge contestants must apply for Phase I by Jan. 31, 2024.

  • Phase II: The second phase will build on the data discovery of selected Phase I teams to focus on advancing state-of-the-art, ethical, and inclusive algorithms and analytic approaches, with an emphasis on tools for predicting early cognitive decline that are clear and easy to explain. Phase II is open to all interested applicants, and Phase I winners are expected to participate in Phase II. Anticipated start date: Sept. 1, 2024.

  • Phase III: The final phase will bring together the top teams in a virtual meeting to present their solution from the previous phase to demonstrate the effectiveness of their algorithmic approaches and to discuss them with experts from NIH and the broader data science community. Phase III is only open to winners of Phase II. Anticipated start date: March 1, 2025.

Prizes are available at each phase of the challenge, ranging from $5,000 to $50,000 for the strongest submissions. Since NIA is particularly interested in advancing equity for populations disproportionately affected by Alzheimer’s and related dementias, Phase 1 winners with proposals to address dementia research and diagnosis biases will also be eligible for bonus prizes. Challenge applicants will be judged by a panel of NIA staff, and the judging criteria are available on the PREPARE challenge website.


Submit ideas for earlier, more accurate dementia risk detection by January 31

If you’re interested in competing in Phase 1 of the PREPARE challenge, be sure to apply online by Jan. 31, 2024. For more information and for more details on the submission process and key dates for each phase, visit the challenge website. If you have questions, please email me or leave a comment below. We wish all applicants good luck in this exciting competition!


About the Workshop

The IMPACT Collaboratory's mission is to build the nation’s capacity to conduct embedded pragmatic clinical trials (ePCTs) in Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD). Training a workforce of investigators prepared to conduct ePCTs of non-pharmacological interventions embedded in healthcare systems is critical to this mission. The IMPACT Collaboratory holds an annual Training Workshop for program participants to develop competence in designing and conducting ePCTs of interventions to improve care for people living with dementia and their care partners.

This virtual 1.5-day workshop that will provide a foundation in practical aspects of designing and conducting ePCTs in AD/ADRD through a combination of panel discussions, small group sessions, and networking opportunities with experts in the field. Participants will gain knowledge in ePCT design and method, problem-solve challenges faced in current or planned projects, and network and engage with the larger community of IMPACT investigators. Throughout the program, special attention is paid to key considerations in designing ePCTs to ensure health equity.


Call for Applications for January 2024 Training Workshop

Wednesday, January 24th, 2024 | 11:00am - 3:30pm ET Thursday, January 25th, 2024 | 11:00am - 5:00pm ET

2024 Modules:

  • Understanding how to carry out sample size estimation for cluster randomized trials

  • Engaging people with lived experience and community partners in ePCTs for dementia

  • Partnering with your healthcare system for an ePCT

The IMPACT Collaboratory will hold the fourth annual Training Workshop on January 24-25, 2024 entitled Building Skills to Conduct Embedded Pragmatic Clinical Trials (ePCTs) among People Living with Dementia (PLWD) and their Care Partners. This 1.5-day virtual workshop features all new material to build a foundation in practical aspects of designing and conducting ePCTs in Alzheimer’s disease (AD) and AD-related dementias (ADRD). The workshop will include a combination of activities including: panel discussions, small group sessions, and networking opportunities with experts in the field.

We are inviting applications from early to mid-stage researchers who seek to develop competence in designing and conducting ePCTs of non-pharmacological interventions embedded in health care systems for PLWD and care partners.

Upon completion of the workshop, participants will be able to:

  • Transmit knowledge about designing and conducting ePCTs among PLWD and care partners in health care systems that integrates considerations related to estimating sample size requirements and establishing and sustaining key partnerships

  • Problem-solve common challenges in designing and conducting ePCTs for PLWD and care partners

  • Apply the acquired knowledge to move their current and future research in ePCTs forward, including applying for competitive funding

Successful applicants will be expected to complete selected readings and online training prior to the workshop. All participants are expected to attend and participate in the entire 1.5-day event.

All participants are expected to attend and participate in the entire 1.5-day event.


APPLICATIONS DUE: October 20, 2023 for the January 2024 Workshop.







  • Career Development Award Program. The NIA IMPACT Collaboratory will fund up to two career development awards (CDAs). These CDAs seek to support the development of early-stage MD, PhD, or equivalent researchers who seek careers conducting embedded pragmatic clinical trials (ePCTs) for people living with AD/ADRD and their care partners. Learn more and submit by September 15, 2023, at 5 PM ET.


  • Health Care System Scholars Program. The NIA IMPACT Collaboratory is issuing a call for Health Care Systems (HCS) Scholars. The HCS Scholars program offers researchers an opportunity to partner with healthcare systems to develop embedded pragmatic clinical trials (ePCTs) focused on improving the care provided to people living with dementia (PLWD) and their care partners (CPs). Learn more and submit a letter of intent by September 26, 2023 at 5 PM ET.


  • Call for Papers: Multidisciplinary Perspectives on Dementia and Population Health Trends. The TRENDS Network at the University of Michigan seeks manuscripts on the topic of dementia and population health trends for an upcoming Supplemental Issue in the Medical Sciences section of the Journal of Gerontology: Series A. Learn more and submit by October 1, 2023.


bottom of page